ea0094oc4.5 | Reproductive Endocrinology | SFEBES2023
Walker Abigail
, Hopkins Thomas
, Howell Lesley
, Farooq Zara
, McCormick Peter
, Jonas Kim
, Hanyaloglu Aylin
Luteinising hormone (LH) and the luteinising hormone receptor (LHR) have key roles in steroidogenesis and ovulation, thus are central targets for fertility treatment. The LHR is a G protein-coupled receptor that predominantly signals through Gαs, although under conditions of high ligand concentration and/or high receptor density, as occurs during the mid-cycle LH surge, can also signal via Gαq/11. Yet, how LHR delineates signal pathway activation to coordinate pleiot...